Lymph is considered as a part of the ISF. ISF has the compositional characteristics of ECF (as mentioned above) but in addition it is distinguished by its usually low protein concentration (in comparison to plasma). Oxygen, nutrients, wastes and chemical messengers all pass through the ISF. The ISF bathes all the cells in the body and is the link between the ICF and the intravascular compartment. This is also a ‘virtual’ fluid (ie it exists in many separate small bits but is spoken about as though it was a pool of fluid of uniform composition in the one location). Interstitial fluid (ISF) consists of all the bits of fluid which lie in the interstices of all body tissues. The ECF compositional similarity is in some ways, the opposite of that for the ICF (ie low in potassium & magnesium and high in sodium and chloride). These compartments are distinguished by different locations and different kinetic characteristics. The ECF is divided into several smaller compartments (eg plasma, Interstitial fluid, fluid of bone and dense connective tissue and transcellular fluid). 2.1.4 Extracellular FluidĪ similar argument applies to the Extracellular Fluid. The use of this convention allows predictions to be made about what will happen with various interventions and within limits these are physiologically meaningful.
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